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Antimicrob Agents Chemother. 1972 January; 1(1): 17-21
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Activity of Lividomycin Against Pseudomonas aeruginosa: Its Inactivation by Phosphorylation Induced by Resistant Strains

Fujio Kobayashi1, Masahito Yamaguchi and Susumu Mitsuhashi

a Department of Microbiology, School of Medicine, Gunma University, Maebashi, Japan

ABSTRACT

The antibacterial activity and enzymatic inactivation of lividomycin, a new aminoglycosidic antibiotic, were studied with 13 strains of Pseudomonas aeruginosa. The minimal inhibitory concentration of lividomycin was 12.5 to 25 µg/ml, and three strains were resistant to high concentrations of lividomycin (more than 200 µg/ml). It was found that P. aeruginosa TI-13 and K-11, highly lividomycin-resistant strains of clinical origin, strongly inactivated the drug. The third resistant strain, Km-41/R, was developed in vitro. Unlike the other resistant strains, Km-41/R, was developed in vitro. Unlike the other resistant strains, Km-41/R did not inactivate the drug, indicating that different mechanisms were involved in lividomycin resistance. By use of a cell-free extract from P. aeruginosa TI-13, the inactivation of lividomycin was found to be caused by the formation of a monophosphorylated product of the drug.

FOOTNOTES

1 Present address: Tokyo Research Laboratories, Kowa Co., Higashimurayama, Tokyo, Japan.

Antimicrob Agents Chemother. 1972 January; 1(1): 17-21
Copyright © 1972 American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Poole, K. (2005). Aminoglycoside Resistance in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 49: 479-487 [Full Text]  


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