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Antimicrob Agents Chemother. 1972 January; 1(1): 78-79
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Tilorone Hydrochloride: Lack of Correlation Between Interferon Induction and Viral Protection

David J. Giron, Jerome P. Schmidt and Frank F. Pindak

Environmental Microbiology Branch, Epidemiology Division, USAF School of Aerospace Medicine (AMD-AFSC), Brooks Air Force Base, Texas 78235

ABSTRACT

The protection of mice against MM virus infection and the induction of circulating interferon by tilorone hydrochloride were determined. Whereas protection was evident with doses of 0.15 and 1.5 mg/kg, interferon was not detected with doses lower than 150 mg/kg. Protection was apparently not dependent on interferon induction.

Antimicrob Agents Chemother. 1972 January; 1(1): 78-79
Copyright © 1972 American Society for Microbiology. All Rights Reserved.





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