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Antimicrob Agents Chemother. 1972 February; 1(2): 143-147
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Effect of Antiviral Agents in Equine Abortion Virus-Infected Hamsters1

Melvin Lieberman, Andrea Pascale, Thomas W. Schafer and Paul E. Came

a Department of Virology, Schering Corporation, Bloomfield, New Jersey 07003

ABSTRACT

Equine abortion virus, a member of the herpesvirus group, produces a lethal infection in hamsters. With this system, the protective effect of certain inhibitors of deoxyribonucleic acid viruses, inducers of interferon and exogenous interferon, was evaluated. Of the various agents studied, 9-ß-D-arabinofuranosyladenine markedly suppressed mortality, and 5-iodo-2'-deoxyuridine, distamycin A, and N-ethylisatin ß-thiosemicarbazone were inactive. Of the inducers tested, statolon, ultraviolet-irradiated Newcastle disease virus, and polyriboinosinic:polyribocytidylic acid (poly I:C) were protective, and endotoxin, polyacrylic acid, and polymethacrylic acid did not protect. Administration of exogenous interferon did not afford protection. Statolon and ultraviolet-irradiated Newcastle disease virus induced circulating interferon in hamsters, whereas poly I:C, endotoxin, and polyacrylic acid did not produce interferon. Because of the severity of the disease produced in hamsters by equine abortion virus, lack of protective activity by an agent in this system should not preclude possible efficacy against other members of the herpesvirus group.

FOOTNOTES

1 Presented in part as a preliminary report at the 69th Annual Meeting of the American Society for Microbiology, 4 to 9 May 1969, Miami Beach, Fla.

Antimicrob Agents Chemother. 1972 February; 1(2): 143-147
Copyright © 1972 American Society for Microbiology. All Rights Reserved.





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Copyright © 1972 by the American Society for Microbiology. All rights reserved.