This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Borders, D. B. Articles by Hausmann, W. K. Search for Related Content PubMed PubMed Citation Articles by Borders, D. B. Articles by Hausmann, W. K.

 Previous Article  |  Next Article 

Antimicrob Agents Chemother. 1972 May; 1(5): 403-407
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Analytical Method for Streptothricin-Type Antibiotics: Structure of Antibiotic LL-BL136¹

Process and Analytical Research Section, Lederle Laboratories, A Division of American Cyanamid Company, Pearl River, New York 10965

ABSTRACT

An analytical procedure was devised which can distinguish members of the streptothricin family of antibiotics. It is based upon an analysis of the hydrolysis products of the antibiotics using a Technicon amino acid autoanalyzer under special conditions. The various fragments including the different streptolidine-amino sugar compounds were well resolved. A basic water-soluble antibiotic discovered in our laboratories and named LL-BL136 was compared to other members of this group by this technique. It was not differentiated from the antibiotic SF-701 reported by Tsuruoka. The autoanalyzer results along with other physicochemical data permitted a structure proposal for this antibiotic, which is the N-methyl-desformimino derivative of antibiotic LL-AC541.

² Deceased.

³ Present address: Ayerst Laboratories, Inc., Rouses Point, N.Y. 12979.

¹ Presented at the Eleventh Interscience Conference on Antimicrobial Agents and Chemotherapy, Atlantic City, N.J., 19–22 October 1971.