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Antimicrob Agents Chemother. 1972 May; 1(5): 427-432
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Reversibility of Protein Binding of Penicillins: an In Vitro Study Employing a Rapid Diafiltration Process

¹ Infectious Disease Service of the New England Medical Center Hospitals, Boston, Massachusetts 02111

ABSTRACT

The reversibility of human serum protein binding of oxacillin, nafcillin, and cephalothin was investigated by using a diafiltration technique. While the temperature, pH, and protein concentration were kept constant, 20% of the serum volume was exchanged every 4 to 5 min. The binding of all three drugs was rapidly reversible, and the percentage of protein binding remained the same throughout the experiment.

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