This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gordon, R. C. Articles by Kirby, W. M. M. Search for Related Content PubMed PubMed Citation Articles by Gordon, R. C. Articles by Kirby, W. M. M.

 Previous Article  |  Next Article 

Antimicrob Agents Chemother. 1972 June; 1(6): 504-507
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Comparative Clinical Pharmacology of Amoxicillin and Ampicillin Administered Orally

¹ Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195

ABSTRACT

Ampicillin and amoxicillin (-amino-p-hydroxybenzyl penicillin) were administered orally in 500-mg doses to eight fasting volunteers in a comparative study in which pharmacokinetic techniques were used. The absorption of amoxicillin was significantly better, as demonstrated by a higher mean peak serum concentration of 7.6 µg/ml as compared to 3.2 µg/ml for ampicillin, an average "area under the curve" that was approximately double that of ampicillin, and an 8-hr urinary recovery for amoxicillin of 60% as compared to 34% for ampicillin. Serum half-lives were the same for the two antibiotics, with values of 60.3 (±3.3) min for ampicillin and 61.3 (±5.6) min for amoxicillin. The latter drug gave measurable concentrations in the blood at 8 hr in all of eight volunteers, as compared to only three of eight with ampicillin.

This article has been cited by other articles:

• Subramanian, S., Roberts, C. L., Hart, C. A., Martin, H. M., Edwards, S. W., Rhodes, J. M., Campbell, B. J. (2008). Replication of Colonic Crohn's Disease Mucosal Escherichia coli Isolates within Macrophages and Their Susceptibility to Antibiotics. Antimicrob. Agents Chemother. 52: 427-434 [Abstract] [Full Text]  
• Humphrey, W. R., Shattuck, M. H., Zielinski, R. J., Kuo, M.-S. T., Biermacher, J. J., Smith, D. P., Jensen, J. L., Schaadt, R. D., Zurenko, G. E., Richards, I. M. (2003). Pharmacokinetics and Efficacy of Linezolid in a Gerbil Model of Streptococcus pneumoniae-Induced Acute Otitis Media. Antimicrob. Agents Chemother. 47: 1355-1363 [Abstract] [Full Text]  
• Piccolomini, R., Di Bonaventura, G., Picciani, C., Laterza, F., Vecchiet, J., Neri, M. (2001). In Vitro Activity of Clarithromycin against Intracellular Helicobacter pylori. Antimicrob. Agents Chemother. 45: 1568-1571 [Abstract] [Full Text]  
• Lim, W. S., Gander, S., Finch, R. G., Macfarlane, J. T. (2000). A novel method for collecting and detecting amoxycillin in urine: a tool for testing antibiotic compliance in the community. J Antimicrob Chemother 46: 835-837 [Abstract] [Full Text]