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Antimicrob Agents Chemother. 1976 July; 10(1): 25-27
Copyright © 1976 American Society for Microbiology. All Rights Reserved.

Pharmacokinetic Parameters of Sisomicin

¹ Department of Medicine, The Mount Sinai School of Medicine of the City University of New York, New York, New York 10029

ABSTRACT

Sisomicin in doses of 1 mg/kg was administered intramuscularly to 10 healthy volunteers, and 1 week later the same volunteers received sisomicin at the same dose intravenously. A peak serum concentration of sisomicin of 3.08 µg/ml was obtained 1 h after intramuscular injection, and a peak serum concentration of 7.12 µg/ml was achieved 30 min after a 30-min intravenous infusion. The sisomicin elimination data were analyzed according to a two-compartment model. Pharmacokinetic parameters derived from the intramuscular and intravenous studies were quite similar.