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Antimicrob Agents Chemother. 1976 August; 10(2): 283-287
Copyright © 1976 American Society for Microbiology. All Rights Reserved.

Pharmacokinetic Interpretation of Cephradine Levels in Serum After Intravenous and Extravascular Administration in Humans

¹ Research and Development Division, Smith Kline and French Laboratories, Philadelphia, Pennsylvania 19101

ABSTRACT

Pharmacokinetic parameters were calculated from intravenous data based upon a two-compartment open model. These parameters were subsequently used to determine the absorption rates and bioavailability of cephradine administered intramuscularly and orally. The results indicate that cephradine obeys dose-independent kinetics and that biological availability is complete from all dosage forms.