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Antimicrob Agents Chemother. 1976 September; 10(3): 447-449
Copyright © 1976 American Society for Microbiology. All Rights Reserved.

Reversible Thrombocytosis and Anemia Due to Miconazole Therapy

^* The Department of Neurology and The Institute for Cardiovascular Diseases, Good Samaritan Hospital, Phoenix, Arizona 85062
Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, San Jose, California 95128

ABSTRACT

Miconazole was administered intravenously in six consecutive patients with, active coccidioidal infection. Such treatment was associated with progressive anemia and thrombocytosis. The hematological abnormalities appeared to be dose related and potentially reversible. Bone marrow studies demonstrated erythroid hypoplasia and increased or active platelet production in three subjects. No hemorrhagic or thrombotic episodes were identified. It is suggested that careful hematological monitoring be performed in subjects undergoing systemic miconazole therapy.