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Antimicrob Agents Chemother. 1976 September; 10(3): 549-554
Copyright © 1976 American Society for Microbiology. All Rights Reserved.

Therapeutic Effects of Ribavirin Given by the Intraperitoneal or Aerosol Route Against Influenza Virus Infections in Mice

¹ United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21701

ABSTRACT

Ribavirin (1-ß-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) is an effective antiviral agent against type A influenza infection of mice. Therapy was most effective when administered as a small-particle aerosol early in the infection. Treatment was also effective by either the intraperitoneal or aerosol route in mice with histological evidence of pneumonia. Ribavirin increased the percent survival, lowered lung virus titers, and decreased the development of lung pathology when therapy was initiated at 6 h as a small-particle aerosol. There was no evidence of pulmonary toxicity or immunosuppressive effects.