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Antimicrob Agents Chemother. 1976 November; 10(5): 856-860
Copyright © 1976 American Society for Microbiology. All Rights Reserved.

Antifungal Properties of Electrically Generated Metallic Ions

T. J. Berger*, J. A. Spadaro, Richard Bierman, S. E. Chapin and R. O. Becker

* Veterans Administration Hospital, Syracuse, New York 13210
Department of Orthopedics, State University of New York, Upstate Medical Center, Syracuse, New York 13210

ABSTRACT

A qualitative and quantitative investigation was undertaken to study the susceptibility of unicellular eucaryotic organisms (yeasts) to metallic cations generated by low levels of direct current. Results were characteristic of effects obtained previously using clinical and standard bacteria test organisms. The present study demonstrated that anodic silver (Ag+) at low direct currents had inhibitory and fungicidal properties. Broth dilution susceptibility tests were made on several species of Candida and one species of Torulopsis. Growth in all isolates was inhibited by concentrations of electrically generated silver ions between 0.5 and 4.7 µg/ml, and silver exhibited fungicidal properties at concentrations as low as 1.9 µg/ml. The inhibitory and fungicidal concentrations of electrically generated silver ions are lower than those reported for other silver compounds.

Antimicrob Agents Chemother. 1976 November; 10(5): 856-860
Copyright © 1976 American Society for Microbiology. All Rights Reserved.



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Copyright © 1976 by the American Society for Microbiology. All rights reserved.