This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Ekwo, E. Articles by Peter, G. Search for Related Content PubMed PubMed Citation Articles by Ekwo, E. Articles by Peter, G.

 Previous Article  |  Next Article 

Antimicrob Agents Chemother. 1976 December; 10(6): 893-898
Copyright © 1976 American Society for Microbiology. All Rights Reserved.

Effect of Clindamycin on Aminoglycoside Activity in a Murine Model of Invasive Escherichia coli Infection

Departments of Pediatrics and Medicine, Roger Williams General Hospital, Providence, Rhode Island 02908; Department of Pediatrics, Rhode Island Hospital, Providence, Rhode Island 02902; and Sections of Reproductive and Developmental Medicine and Medicine, Brown University Program in Medicine, Providence, Rhode Island 02908

ABSTRACT

Previous studies have demonstrated that the early in vitro bactericidal activity of gentamicin and amikacin is inhibited by clindamycin. To investigate the possible clinical implications of these findings, the effect of clindamycin in combination with gentamicin or amikacin was compared with that of the aminoglycoside alone in the treatment of normal and neutropenic mice with Escherichia coli peritonitis and bacteremia. Mice treated with saline or clindamycin alone experienced rapid multiplication of bacteria in the peritoneal cavity, bacteremia, and subsequent death. Gentamicin or amikacin given 2 h after E. coli inoculation significantly reduced the mortality and peritoneal bacterial counts in normal and neutropenic mice in comparison with untreated controls. Prior or simultaneous administration of clindamycin with either aminoglycoside did not inhibit survival or bacterial clearance from the peritoneum. The only clindamycin effect was slight enhancement of survival of neutropenic mice treated with multiple doses of amikacin and clindamycin in comparison to those treated with amikacin alone.

¹ Present address: Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, IA 52242.

² Address reprint requests to: Dr. Georges Peter, Division of Infectious Diseases, Rhode Island Hospital, Providence, RI 02902.