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Antimicrob Agents Chemother. 1976 December; 10(6): 918-920
Copyright © 1976 American Society for Microbiology. All Rights Reserved.

Comparative In Vitro Studies of Cinoxacin, Nalidixic Acid, and Oxolinic Acid

^a Departments of Human Development, Medicine, and Microbiology and Public Health, Michigan State University, East Lansing, Michigan 48824

ABSTRACT

Cinoxacin and nalidixic acid were found to be similar in in vitro activity against 138 Shigella isolates and somewhat less active than oxolinic acid on a weight basis. Cross-resistance developed when 10 shigellae were transferred on increasing amounts of the respective agent contained in Mueller-Hinton agar. Plate dilution studies of the effect of changes in agar pH on the minimum inhibitory concentration revealed that the antibacterial activity increased with decreasing pH. Protein binding investigations revealed a high degree of binding, with nalidixic acid > oxolinic acid > cinoxacin.

¹ Present address: Infectious Disease Research Laboratory, A. P. Beutel Health Center, Texas A & M University, College Station, TX 77843.