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Antimicrob Agents Chemother. 1977 January; 11(1): 110-113
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Comparative Penetration of Amikacin, Gentamicin, and Penicillin G into Exudate Fluid in Experimental Sterile Peritonitis

¹ Infectious Diseases Section, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19174

ABSTRACT

Using a rabbit sterile peritonitis model, we compared the penetration of intravenously administered amikacin, gentamicin, and penicillin G into peritoneal exudate. Peritonitis was induced with sterile normal saline, and the peritoneal exudate contained 23,751 ± 3,039 granulocytes 8 h later. Antibiotics were administered intravenously 3 h after initiating peritonitis, and serum and peritoneal fluid concentrations were measured for 5 h. Peritoneal levels of each antibiotic exceeded simultaneous serum levels by 1 h after dose and remained above serum levels thereafter. The maximum peritoneal fluid concentration of amikacin reached 71.2% ± 12.7 of the maximum serum concentration, whereas maximum gentamicin peritoneal concentration achieved 37.1% ± 2.7, and penicillin achieved 23.2% ± 4.5, of their respective maximum serum concentrations.

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