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Antimicrob Agents Chemother. 1977 January; 11(1): 167-170
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Nalidixic Acid-Induced Protein Alterations in Escherichia coli

Lee Chao

1 Department of Biochemistry, Medical University of South Carolina, Charleston, South Carolina 29401

ABSTRACT

The effect of nalidixic acid on pulse-labeled protein patterns was analyzed by sodium dodecyl sulfate-polyacrylamide slab gel electrophoresis. The drug was found to alter protein patterns in a drug-sensitive strain but not in the isogenic drug-resistant strain of Escherichia coli. The drug-induced alteration of protein patterns was demonstrated by the appearance of some and the disappearance of other pulse-labeled peptides elicited by the drug.

Antimicrob Agents Chemother. 1977 January; 11(1): 167-170
Copyright © 1977 American Society for Microbiology. All Rights Reserved.





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Copyright © 1977 by the American Society for Microbiology. All rights reserved.