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Antimicrob Agents Chemother. 1977 January; 11(1): 174-175
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Stability of Cephalosporins in Horse Serum

The Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46206

ABSTRACT

The antibiotic activity of cephalothin, cephaloridine, cephalexin, cephaloglycin, cefazolin, and cefamandole was determined after storage for up to 30 days in horse serum at –10 and 4°C. Cephalothin, cefamandole, cefazolin, and cephalexin were stable for at least 30 days at –10°C, whereas cephaloridine lost 29% of its initial activity and cephaloglycin lost more than 50%. Cefamandole, cefazolin, and cephalexin could only be stored for 3 days at 4°C without significant loss in activity, whereas cephalothin, cephaloridine, and cephaloglycin could be stored for only 1 day. Repeated freezing and thawing had a detrimental effect on the stability of cephaloridine.