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Antimicrob Agents Chemother. 1977 January; 11(1): 21-25
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Therapy of Murine Aspergillosis with Amphotericin B in Combination with Rifampin or 5-Fluorocytosine

^* Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110
¹ Division of Dermatology, and Laboratory Medicine, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110

ABSTRACT

Suboptimal doses of amphotericin B in combination with either rifampin or 5-fluorocytosine were better than single-drug therapy in the treatment of disseminated Aspergillus fumigatus infection in mice. Despite the increased effectiveness of combination therapy, none of the therapeutic regimens we used completely eradicated infections in the mice when evaluated by mycological culture, even in long-term survivors.

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