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Antimicrob Agents Chemother. 1977 January; 11(1): 44-46
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Microassay for Amphotericin B

¹ Department of Bacteriology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada

ABSTRACT

Depending on the hematocrit, duplicate or triplicate determinations of serum amphotericin B concentration may be made on as little as 100 µl of capillary blood obtained by finger prick. In an accurate plate diffusion bioassay, using Paecilomyces varioti as the indicator organism, levels of the drug in the therapeutic range can be determined fast enough for clinicians to modify their next dose.

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