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Antimicrob Agents Chemother. 1977 January; 11(1): 47-50
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Mechanisms of Gentamicin Resistance in Staphylococcus aureus

Department of Pharmacology, University of Cambridge Medical School, Cambridge CB2 2QD, England

ABSTRACT

Three clinical isolates of Staphylococcus aureus resistant to gentamicin and other aminoglycosides have been examined for antibiotic modifying enzymes. The strains contain a number of these enzymes, most of them similar to those commonly found in aminoglycoside-resistant gram-negative strains. All three strains (and a transductant derived from one of them) contain two enzymes mediating gentamicin resistance, an aminoglycoside 6'-N-acetyltransferase and a novel enzyme, gentamicin phosphotransferase.

¹ Present address: Department of Biochemistry, Adrian Building, University of Leicester, Leicester, England.