AAC
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sammons, M. L.
Right arrow Articles by Hilmas, D. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sammons, M. L.
Right arrow Articles by Hilmas, D. E.

 Previous Article  |  Next Article 

Antimicrob Agents Chemother. 1977 January; 11(1): 80-83
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Interferon Induction in Cynomolgus and Rhesus Monkeys After Repeated Doses of a Modified Polyriboinosinic-Polyribocytidylic Acid Complex

M. L. Sammons1, E. L. Stephen*, H. B. Levy1, S. Baron1 and D. E. Hilmas1

* U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21701,
1 National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 21714, University of Texas Medical Branch, Galveston, Texas 77550

ABSTRACT

Serum interferon activity was determined in 12 cynomolgus and 12 rhesus monkeys injected intravenously once daily for 10 days with from 0.1 to 6.0 mg of a stabilized polyriboinosinic acid · polyribocytidylic acid complex per kg, composed of polyriboinosinic acid · polyribocytidylic acid, poly-1-lysine, and carboxymethylcellulose [poly(ICLC)]. Interferon activity was detected 2 h after the first injection, with maximum activity occurring 8 h after the second injection. A period of hyporesponsiveness occurred after the third injection of poly(ICLC) in all monkeys and lasted until the sixth injection in the rhesus monkeys, when interferon activity again became more elevated. The delayed rebound was not as apparent in cynomolgus monkeys. Rhesus monkeys injected with 6 mg/kg did not exhibit serious side effects.

Antimicrob Agents Chemother. 1977 January; 11(1): 80-83
Copyright © 1977 American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Clin. Vaccine Immunol. Clin. Microbiol. Rev.
J. Clin. Microbiol. ALL ASM JOURNALS

Copyright © 1977 by the American Society for Microbiology. All rights reserved.