This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Wagner, G. E. Articles by Shadomy, S. Search for Related Content PubMed PubMed Citation Articles by Wagner, G. E. Articles by Shadomy, S.

 Previous Article  |  Next Article 

Antimicrob Agents Chemother. 1977 February; 11(2): 229-233
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Effects of Purines and Pyrimidines on the Fungistatic Activity of 5-Fluorocytosine in Aspergillus Species

Division of Infectious Diseases, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298

ABSTRACT

The ability of some exogenously supplied purines, pyrimidines, and their nucleosides to antagonize the in vitro fungistatic activity of 5-fluorocytosine (5-FC) in Aspergillus species was examined. All compounds tested except thymidine were capable of altering the minimal inhibitory concentration of 5-FC for seven strains of aspergilli tested. In most instances, there was a reciprocal correlation between the ability of a compound to antagonize the fungistatic activity of 5-FC and the quantity of 5-FC taken up by cells in the presence of the compound over a 72-h period.