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Antimicrob Agents Chemother. 1977 February; 11(2): 240-243
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Antimicrobial Prophylaxis for Catheter-Associated Bacteriuria

¹ Departments of Medicine (Infectious Diseases), Medical Biophysics and Computing, and Obstetrics and Gynecology, University of Utah College of Medicine and LDS Hospital, Salt Lake City, Utah 84143

ABSTRACT

We evaluated short-term systemic antimicrobial prophylaxis for catheter-associated bacteriuria in women undergoing elective gynecological operations in a prospective, controlled, double-masked study. Nine of 100 placebo-treated patients acquired bacteriuria during catheterization compared with 3 of 96 of the drug-treated group. However, at the time of hospital discharge, clean-voided urine specimens were positive as frequently in the drug-treated group (8 of 82 patients cultured) as in the placebo group (8 of 75 patients cultured). No difference in febrile morbidity due to bacteriuria was noted between the prophylaxis and placebo groups. The incidence of catheter-associated bacteriuria may be reduced by antimicrobial prophylaxis. However, because the protective effect is transient and is associated with the selection of resistant organisms, prophylaxis is not indicated for patients at low risk for acquired bacteriuria and in whom the sequelae of catheter-associated infections are infrequent.

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