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Antimicrob Agents Chemother. 1977 February; 11(2): 248-250
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Pharmacokinetics of Cefamandole in Patients with Renal Failure

¹ Department of Medicine, The Mount Sinai School of Medicine of the City University of New York, New York, New York 10029

ABSTRACT

The pharmacokinetics of cefamandole were studied in four patients with stable renal failure, two patients undergoing peritoneal dialysis, and four patients undergoing hemodialysis. Peak concentrations of cefamandole in serum were achieved 1 to 2 h after intramuscular injection in the patients with stable renal impairment, and the concentrations declined slowly, with half-life values of 12.3 to 18 h. Cefamandole was removed only very slowly by peritoneal dialysis. Hemodialysis was more efficient in removing cefamandole, with serum half-life values ranging from 3.8 to 7.9 h. The mean apparent volume of distribution of cefamandole in these 10 patients was 21.92 liters, or 31% of the body weight.