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Antimicrob Agents Chemother. 1977 February; 11(2): 251-257
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Changes in Superhelical Density of Closed Circular Deoxyribonucleic Acid by Intercalation of Anti-R-Plasmid Drugs and Primaquine

¹ Department of Molecular Biology, Walter Reed Army Institute of Research, Washington, D.C. 20012

ABSTRACT

The following compounds, which possess anti-R-plasmid activity (Hahn and Ciak, 1976) in decreasing order, were shown by viscometric titration to change systematically the superhelical density of closed circular PM2 deoxyribonucleic acid in the manner of intercalators: ethidium bromide, quinacrine, acridine orange, quinine, chlorpromazine, chloroquine, and methylene blue. The same effect was caused by the antimalarial drug primaquine, which has not been tested for antiplasmid activity.