This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Cesario, T. C. Articles by Tilles, J. G. Search for Related Content PubMed PubMed Citation Articles by Cesario, T. C. Articles by Tilles, J. G.

 Previous Article  |  Next Article 

Antimicrob Agents Chemother. 1977 February; 11(2): 291-298
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Relationship Between the Physicochemical Nature of Human Interferon, the Cell Induced, and the Inducing Agent

Department of Medicine, California College of Medicine, University of California, Irvine, California 92664

ABSTRACT

To determine the basis for differences in interferons previously noted by others, we prepared five types of human interferon, namely interferon induced in muscle skin fibroblasts using complexed polyinosinic:polycytidylic acid (IC) and Newcastle disease virus (NDV), and interferon induced in leukocytes using IC, NDV, and phytohemagglutinin. We determined the molecular weight, isoelectric point, inactivation rate at 56°C and structural activity relationships for each interferon. Significant differences between these interferons were found, many of which seem related to the cell induced rather than the inducer. We believe these findings have important pharmacological implications for the use of interferon in man.

¹ Present address: University of California Irvine Medical Center, 101 City Drive South, Orange, CA 92668.