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Antimicrob Agents Chemother. 1977 February; 11(2): 369-371
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Antimicrobial Activity of Cefamandole Against Salmonella typhi

^* Division of Infectious Diseases Department of Medicine, Mount Sinai School of Medicine of the City University of New York, New York, 10029
² Division of Pulmonary Diseases, Department of Medicine, Mount Sinai School of Medicine of the City University of New York, New York, 10029

ABSTRACT

A patient with Salmonella typhi bacteremia was sucessfully treated with cefamandole, a new cephalosporin derivative. Infection has not recurred during 6 months of follow-up observation. Minimum inhibitory concentrations and minimum bactericidal concentrations of cefamandole, cephalothin, ampicillin, and chloramphenicol were compared against 26 strains of S. typhi. All the strains were susceptible to cefamandole in vitro. Seven of the strains were resistant to chloramphenicol, and another seven were resistant to both chloramphenicol and ampicillin. Cefamandole appears to warrant further clinical trial for the treatment of typhoid fever.