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Antimicrob Agents Chemother. 1977 March; 11(3): 373-375
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Cairomycin B, a New Antibiotic

Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt Arab Republic

ABSTRACT

Cairomycin B is a new cyclic peptide antibiotic that was isolated from Streptomyces As-C-19 obtained from the soil of Cairo. The antibiotic had the following empirical formula: C₁₀H₁₅N₃O₃; on acid hydrolysis, it yielded aspartic acid and lysine. Spectral analysis and its chemical characteristics indicated that it was a cyclic peptide. The antibiotic melted at 120 to 121°C and was freely soluble in chloroform, ethyl acetate, and acetone, slightly soluble in alcohols, and rather insoluble in water and petroleum ether. Cairomycin B was mainly active against gram-positive bacteria, with high toxicity to experimental animals and weak serum-binding properties.