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Antimicrob Agents Chemother. 1977 March; 11(3): 388-391
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Changing Patterns of Plasmid-Mediated Drug Resistance During Tetracycline Therapy

J. K. Møller*, A. Leth Bak1, A. Stenderup1, H. Zachariae1 and H. Afzelius1

* Institute of Medical Microbiology, Bartholin Building, University of Aarhus, Dk-8000 Aarhus C, Denmark,
Department of Dermatology, Marselisborg Hospital, Aarhus, Denmark

ABSTRACT

The patterns of drug resistance and the frequency of conjugative R plasmids in intestinal Escherichia coli from 88 patients treated for a skin disease (acne vulgaris) with low oral doses of tetracycline are reported. The proportion of patients with resistant bacteria was progressively greater in patients who received tetracycline for 1 week, 4 weeks, or longer (from 50 to 88%). No multiply drug-resistant bacteria were detected before treatment or after 1 week of treatment. After more than 4 weeks of treatment, multiply drug-resistant E. coli were isolated from about 50% of the patients. The origin and selection of R plasmid-determined multiple drug resistance are discussed.

Antimicrob Agents Chemother. 1977 March; 11(3): 388-391
Copyright © 1977 American Society for Microbiology. All Rights Reserved.



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