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Antimicrob Agents Chemother. 1977 March; 11(3): 392-395
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Effect of Penicillin on Streptomycin Production by Streptomyces griseus

¹ Institute of Biology, University of Medicine, H-4012, Debrecen, Hungary

ABSTRACT

The correlation between the biosynthesis of the cell wall and the formation of streptomycin (SM) in Streptomyces griseus, influenced by a specific inhibitor of cell wall synthesis, was investigated. Penicillin, in subinhibitory concentrations (1 to 5 µg/ml), was added to cultures of S. griseus in different stages of its life cycle. The inhibitor decreased SM production, when young cultures were treated; however, there was an increase in SM formation when penicillin was added to older cultures. The explanation for these findings is discussed in detail.