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Antimicrob Agents Chemother. 1977 March; 11(3): 396-401
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Gardimycin, a New Antibiotic Inhibiting Peptidoglycan Synthesis

Research Laboratories, Lepetit S.p.A., Milano, Italy

ABSTRACT

Gardimycin, a new antibiotic, at 100 µg/ml, specifically inhibited cell wall synthesis and induced accumulation of uridine 5'-diphosphate-N-acetylmur-amylpentapeptide in whole cells of Bacillus subtilis. The antibiotic was active in a particulate enzyme preparation from Bacillus stearothermophilus: 60 µg/ml caused 50%, and 200µg/ml caused 100%, inhibition of peptidoglycan synthesis. Suppression of peptidoglycan synthesis was accompanied by parallel accumulation of the lipid intermediate. This mechanism of action is discussed in comparison with those of other antibiotics that are known to inhibit bacterial cell wall biosynthesis.

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