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Antimicrob Agents Chemother. 1977 March; 11(3): 402-406
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Antibacterial Activity of Netilmicin, a New Aminoglycoside Antibiotic, Compared with That of Gentamicin

¹ Department of Microbiology, St. Thomas's Hospital Medical School, London SE1 7EH, England

ABSTRACT

The antibacterial activity of netilmicin (Sch 20569), a new semisynthetic aminoglycoside, was compared with that of gentamicin against a variety of gram-negative bacteria, staphylococci, and streptococci. Both antibiotics had similar activity against most organisms, but netilmicin had appreciably greater activity against gram-negative organisms that were resistant to gentamicin because these species synthesized aminoglycoside 3-N-acetyltransferase I or aminoglycoside 2''-O-nucleotidyltransferase. Netilmicin was also more active than gentamicin against gentamicin-resistant strains of Staphylococcus aureus that produced two enzymes–aminoglycoside-2''-O-phosphotransferase and aminoglycoside-6'-N-acetyltransferase.