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Antimicrob Agents Chemother. 1977 March; 11(3): 407-410
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

In Vivo Effects of Josamycin, Erythromycin, and Placebo Therapy on Nasal Carriage of Staphylococcus aureus

Samuel Z. Wilson, R. Russell Martin and Margaret Putman

Departments of Microbiology and Immunology, and Medicine, Baylor College of Medicine, Houston, Texas 77030

ABSTRACT

Healthy nasal carriers of Staphylococcus aureus were randomly assigned to one of three treatment regimens: josamycin (1.5 g/day), erythromycin stearate (1.0 g/day), or placebo, each administered orally for 7 days. Quantitative nasal cultures were obtained from each subject at intervals before, during, and after treatment. All 25 placebo-treated subjects had positive nasal cultures for S. aureus at all culture intervals. Both josamycin and erythromycin were equally effective in reducing the carrier rates and in decreasing the total numbers of S. aureus isolated from subjects with positive cultures during treatment. No increase in in vitro antibiotic resistance was detected in isolates obtained after therapy. Both antibiotics were well tolerated, and toxicity was not encountered with either drug.

Antimicrob Agents Chemother. 1977 March; 11(3): 407-410
Copyright © 1977 American Society for Microbiology. All Rights Reserved.



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