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Antimicrob Agents Chemother. 1977 March; 11(3): 435-440
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Chemotherapy of an Experimental Bacteroides fragilis Infection in Mice

¹ Anaerobe Laboratory, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061

ABSTRACT

The efficacies of five common antimicrobial agents were determined for a pure Bacteroides fragilis infection in mice. Therapy was begun 4 h after bacterial injection and given every 8 h thereafter for 5 days. Blood levels were determined over an 8-h period for each concentration of antibiotic tested. Clindamycin and tetracycline were the most effective in preventing the formation of abscesses. Chloramphenicol, penicillin G, and cephalothin were not effective in protecting the mice from infection.

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