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Antimicrob Agents Chemother. 1977 March; 11(3): 441-448
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Pirbenicillin: Comparison with Carbenicillin and BL-P1654, Alone and with Gentamicin, Against Pseudomonas aeruginosa

^* Department of Medicine, Veterans Administration Hospital, University of Maryland School of Medicine, Baltimore, Maryland 21218
¹ Baltimore Cancer Research Center, Baltimore, Maryland 21218

ABSTRACT

Minimum inhibitory concentrations (MIC) of pirbenicillin against 135 clinical isolates of Pseudomonas aeruginosa were one-fourth of those required for carbenicillin but two times higher than those for BL-P1654. Increasing the inoculum size produced an adverse effect on the bactericidal activity for all three antibiotics. This was more apparent for pirbenicillin than for carbenicillin, but less than the effect on BL-P1654. When concentrations of antibiotics likely to be achieved clinically were used, gentamicin increased the inhibitory and bactericidal effects of all three semisynthetic penicillins for the majority of isolates. Strains highly resistant to the aminoglycoside antibiotic, however, were inhibited no more by the penicillin-gentamicin combinations than by the most effective of the antibiotics alone.