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Antimicrob Agents Chemother. 1977 March; 11(3): 451-454
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Comparison of the Actions of 5-Fluorouracil and Ftorafur in Escherichia coli

Department of Developmental Therapeutics, The University of Texas System Cancer Center, M.D. Anderson Hospital and Tumor Institute, Houston, Texas 77030

ABSTRACT

The actions of 5-fluorouracil (FU) and Ftorafur (NCS 148958) were compared in Escherichia coli B3 to determine if Ftorafur can act in ways other than through the production of FU. Very high concentrations of Ftorafur relative to FU were necessary to achieve a comparable inhibition of cell growth. Inhibition by both agents could be reversed by uracil. An FU-resistant strain and an Ftorafur-resistant strain were isolated and found to be cross-resistant to Ftorafur and FU, respectively.