Previous Article | Next Article ![]()
Antimicrob Agents Chemother. 1977 March; 11(3): 491-499
Copyright © 1977 American Society for Microbiology. All Rights Reserved.
Department of Biochemistry, College of Agricultural and Life Sciences, University of WisconsinMadison, Madison, Wisconsin 53706
ABSTRACT
The 12,13-epoxytrichothecenes, specific inhibitors of protein synthesis in eukaryotes, can be subdivided further in terms of their mode of action. In addition to the I-type (initiation inhibitors) and E-types (elongation inhibitors), we found that some E-types apparently exhibit inhibition of chain termination at low concentrations. The nature of substituents on C4 may determine the type of inhibitory activity observed.
1 Present address: Department of Pharmacology, Cambridge University Medical School, Cambridge CB2 2QD, England.
This article has been cited by other articles:
Copyright © 2009 by the American Society for Microbiology. For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»