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Inhibition of Initiation, Elongation, and Termination of Eukaryotic Protein Synthesis by Trichothecene Fungal Toxins

Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin–Madison, Madison, Wisconsin 53706

ABSTRACT

The 12,13-epoxytrichothecenes, specific inhibitors of protein synthesis in eukaryotes, can be subdivided further in terms of their mode of action. In addition to the I-type (initiation inhibitors) and E-types (elongation inhibitors), we found that some E-types apparently exhibit inhibition of chain termination at low concentrations. The nature of substituents on C4 may determine the type of inhibitory activity observed.

¹ Present address: Department of Pharmacology, Cambridge University Medical School, Cambridge CB2 2QD, England.

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