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Antimicrob Agents Chemother. 1977 March; 11(3): 500-513
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Cytochemical and Biochemical Studies of Yeasts After In Vitro Exposure to Miconazole

Laboratories of Cell Biology and Biochemistry, Janssen Pharmaceutica, Research Laboratories, 2340 Beerse, Belgium

ABSTRACT

Yeast cells exposed to different doses of the antimycotic agent miconazole revealed important cytochemical changes in the topographic distribution of the phosphatases. A strong effect was observed on the behavior of oxidative and peroxidative enzymes. Decreased cytochrome c oxidase and peroxidase activity and increased catalase activity were seen after treatment with a fungistatic dose of miconazole, whereas a complete disappearance of these enzymes was observed after treatment with a minimal fungicidal dose of miconazole. This was in complete agreement with the quantitative biochemical data. A hypothesis is advanced concerning the possible involvement of peroxidase and catalase in the mechanism of action of this drug.

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