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Antimicrob Agents Chemother. 1977 March; 11(3): 521-527
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Inhibition of Cellular and Viral Protein Synthesis by 3-Methyleneoxindole

Biochemistry and Biophysics Section, University of Connecticut, Storrs, Connecticut 06268

ABSTRACT

The effect of 3-methyleneoxindole (MO) on mengovirus and L-cell protein synthesis was investigated. MO was found to inhibit mengovirus multiplication and the incorporation of radioactive amino acids into both viral and cellular proteins. These results suggest that the antiviral effect of this compound is not specific but rather stems from its inhibition of the cellular translational machinery upon which mengovirus depends. We have also found that MO inhibits natural messenger ribonucleic acid (mengovirus and globin messenger ribonucleic acid) translation in cell-free extracts from Ehrlich ascites tumor cells but has no significant effect on polyuridylic acid translation. Additional data which suggest that MO inhibits protein synthesis at the level of initiation are shown.

¹ Laboratory of Reproductive Physiology, University of Pennsylvania, Philadelphia, PA 19174.