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Antimicrob Agents Chemother. 1977 March; 11(3): 528-533
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Plasmid-Mediated Beta-Lactamase Production in Neisseria gonorrhoeae

Lynn P. Elwell, Marilyn Roberts, Leonard W. Mayer and Stanley Falkow

1 Department of Microbiology and Immunology, University of Washington School of Medicine, Seattle, Washington 98195

ABSTRACT

Several ß-lactamase-producing, penicillin-resistant strains of Neisseria gonorrhoeae were examined for R plasmids. Penicillin-resistant strains isolated from men returning from the Far East and their contacts contained a 4.4 x 106-dalton plasmid in common. Transformation studies and the isolation of a spontaneous penicillin-susceptible segregant showed that the structural gene for ß-lactamase was part of the 4.4 x 106-dalton plasmid. An additional penicillin-resistant gonococcal strain isolated in London was found to harbor a 3.2 x 106-dalton R plasmid. Deoxyribonucleic acid (DNA)-DNA duplex studies revealed that the penicillin-resistant gonococcal isolates contained a significant portion (about 40%) of the transposable DNA sequence, TnA, which includes the ß-lactamase gene commonly found on R plasmids of the Enterobacteriaceae and Haemophilus influenzae.

Antimicrob Agents Chemother. 1977 March; 11(3): 528-533
Copyright © 1977 American Society for Microbiology. All Rights Reserved.



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