AAC
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Andrews, F. A.
Right arrow Articles by Sarosi, G. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Andrews, F. A.
Right arrow Articles by Sarosi, G. A.

 Previous Article  |  Next Article 

Antimicrob Agents Chemother. 1977 April; 11(4): 615-618
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Influence of Antioxidants on the Bioactivity of Amphotericin B

Fred A. Andrews, William H. Beggs and George A. Sarosi

1 General Medical Research Service, Veterans Administration Hospital, Minneapolis, Minnesota 55417

ABSTRACT

Four antioxidants, propyl gallate, butylated hydroxyanisole, butylated hydroxytoluene, and D-{alpha}-tocopherol acid succinate were found to stabilize amphotericin B and to prolong its antifungal activity against Candida albicans. Although each of the antioxidants was effective in this respect, propyl gallate and butylated hydroxyanisole were better than butylated hydroxytoluene and D-{alpha}-tocopherol acid succinate. None of the antioxidants alone adversely affected normal cell growth. It is suggested that amphotericin B instability is due, at least in part, to lability of the carbon-carbon double bonds of the polyene moiety toward autoxidation. By protecting the drug molecule with an antioxidant, it is possible to significantly lower the quantity of AB necessary to obtain particular antifungal effects.

Antimicrob Agents Chemother. 1977 April; 11(4): 615-618
Copyright © 1977 American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Clin. Vaccine Immunol. Clin. Microbiol. Rev.
J. Clin. Microbiol. ALL ASM JOURNALS

Copyright © 1977 by the American Society for Microbiology. All rights reserved.