This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Postic, B. Articles by Dowling, J. N. Search for Related Content PubMed PubMed Citation Articles by Postic, B. Articles by Dowling, J. N.

 Previous Article  |  Next Article 

Antimicrob Agents Chemother. 1977 April; 11(4): 656-660
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Susceptibility of Clinical Isolates of Cytomegalovirus to Human Interferon

¹ Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15240
^* Medical Service, the Oakland Division of the Veterans Administration Hospital, Pittsburgh, Pennsylvania 15240

ABSTRACT

Human cell culture-derived interferon was shown to inhibit human cytomegalovirus in vitro. A prototype strain, Davis, and six clinical isolates of cytomegalovirus were tested. All six isolates showed uniform susceptibility to interferon, exceeding that of the Davis strain by two- to fourfold. The latter virus was found to be 32 to 4 times less susceptible than the sensitive indicator, vesicular stomatitis virus. However, the laboratory finding of susceptibility to an antiviral material may not relate to its clinical effectiveness.