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Antimicrob Agents Chemother. 1977 June; 11(6): 1027-1032
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Effects of Gestational Age, Birth Weight, and Hypoxemia on Pharmacokinetics of Amikacin in Serum of Infants

Martin G. Myers, Robert J. Roberts and Najwa J. Mirhij

Divisions of Infectious Diseases and Clinical Pharmacology, the Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242

ABSTRACT

The serum pharmacokinetics of amikacin were studied in 36 infants treated for suspected bacterial infection. A prolonged serum half-life was associated with the related variables of birth at an early gestational age, low birth weight, and hypoxemia. A postnatal age effect was not apparent when hypoxemic infants were excluded.

Antimicrob Agents Chemother. 1977 June; 11(6): 1027-1032
Copyright © 1977 American Society for Microbiology. All Rights Reserved.





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Copyright © 1977 by the American Society for Microbiology. All rights reserved.