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Antimicrob Agents Chemother. 1977 June; 11(6): 1042-1048
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Exudate Levels and Bactericidal Activity of Cefazolin in a New Local Infection System Using Rat Granuloma Pouches

Minoru Nishida and Takeo Murakawa

Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka 532, Japan

ABSTRACT

An experimental local infection system has been developed in which exudates are induced with croton oil in granuloma pouches of rats. This system provided a suitable model for the evaluation of the therapeutic effect of two antibiotics, cefazolin and cephalothin. Exudate levels of cefazolin were found to be higher than those of cephalothin, and these levels correlated with the higher serum level of cefazolin. The therapeutic effect of cefazolin, after intramuscular injection of 20 mg of each antibiotic per kg, was superior to that of cephalothin in eradicating both Staphylococcus aureus and Escherichia coli.

Antimicrob Agents Chemother. 1977 June; 11(6): 1042-1048
Copyright © 1977 American Society for Microbiology. All Rights Reserved.





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