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Antimicrob Agents Chemother. 1977 June; 11(6): 1069-1070
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Response of Influenza Virus-Infected Mice to Selected Doses of Ribavirin Administered Intraperitoneally or by Aerosol

^a U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21701

ABSTRACT

The effects of graded doses of ribavirin administered either by aerosol or intraperitoneally were compared in influenza virus-infected mice. The median effective dose values (based upon percent survival) were 3.3 and 15.8 mg/kg per day for the aerosol and intraperitoneal routes, respectively. Lung lesion scores and titer of virus were lower after aerosol than intraperitoneal therapy.

¹ Present address: Plum Island Animal Disease Center, P.O. Box 848, Greenport, NY 11944.