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Antimicrob Agents Chemother. 1977 June; 11(6): 1077-1078
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Effect of Anaerobiosis on Antimicrobial Susceptibility of Staphylococci¹

^a Department of Microbiology, North Carolina State University, Raleigh, North Carolina 27607

ABSTRACT

The minimum inhibitory concentration (MIC) of 12 antibiotics was determined for four strains of staphylococci (representing the three major species) under aerobic and anaerobic conditions by using the broth dilution method. Nine of the antibiotics showed no significant difference between aerobic and anaerobic MIC for any of the four cultures. Gentamicin and kanamycin showed a small, but significant, increase in MIC for at least two strains under anaerobic conditions. Trimethoprim was less effective against all strains under anaerobic conditions.

¹ Paper no. 5156 of the Journal Series of the North Carolina Agricultural Experiment Station, Raleigh, N.C.