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Antimicrob Agents Chemother. 1977 June; 11(6): 1081-1083
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Distribution of Amikacin in Serum, Muscle, and Fat in Children After a Single Intramuscular Injection

^a Division of Antimicrobial Therapy, Children's Hospital, and Department for Pediatric Surgery, University of Munich, 8000 Munich 2, Federal Republic of Germany

ABSTRACT

Amikacin concentrations in serum, muscle, and fat were determined in 41 children after intramuscular administration of 7.5 mg/kg of body weight. At 1.5 h amikacin reached peak concentrations in serum (mean value, 14.9 µg/ml) as well as in muscle (2.2 µg/g) and fat (1.89 µg/g) tissue; from then on all concentrations declined. Amikacin concentrations exceeded 1 µg/g in muscle for at least 3 h and in fat for at least 4 h.

¹ Present address: Klinikhygieniker des Universitätsklinikums Freiburg, 7800 Freiburg, Federal Republic of Germany.