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Antimicrob Agents Chemother. 1977 June; 11(6): 946-951
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Inhibition of Influenza Virus Ribonucleic Acid Polymerase by Ribavirin Triphosphate

Research and Development Laboratories, Astra Läkemedel AB, Södertälje, and Department of Microbiology, Biomedical Center, University of Uppsala, Uppsala, Sweden

ABSTRACT

Ribavirin 5'-triphosphate (RTP), derived from the broad-spectrum antiviral compound ribavirin (Virazole), can selectively inhibit influenza virus ribonucleic acid polymerase in a cell-free assay. Ribavirin and its 5'-monophosphate have no effect on the polymerase. The inhibition is competitive with respect to adenosine 5'-triphosphate and guanosine 5'-triphosphate. RTP also inhibits ApG- and GpC-stimulated influenza virus ribonucleic acid polymerase. Since ribavirin is phosphorylated in the cell, the inhibition of influenza multiplication in the cell may also be caused by RTP.

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