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Antimicrob Agents Chemother. 1977 July; 12(1): 26-30
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

2''-O-Phosphorylation of Gentamicin Components by a Staphylococcus aureus Strain Carrying a Plasmid

^* Centre d'Etude et de Recherche de Chimie Organique Appliquée, Centre National de la Recherche Scientifique, 94320 Thiais
¹ Centre Hospitalier Universitatire Henri-Mondor, 94010 Créteil, France

ABSTRACT

A wild-type strain of Staphylococcus aureus that inactivates the 4,6-glycosidically linked deoxystreptamine aminoglycoside antibiotics by a plasmid-mediated process was found to harbor two enzymes: an acetyltransferase of the AAC(6') type and a new phosphotranferase specific to the gentamicin components. The target of this last enzyme is the 2''-hydroxyl function of these antibiotics, since one inactivated compound is 2''-(O)-phosphorylsisomicin.