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Antimicrob Agents Chemother. 1977 July; 12(1): 31-36
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

In Vitro Activity of p-Hydroxybenzyl Penicillin (Penicillin X) and Five Other Penicillins Against Neisseria gonorrhoeae: Comparisons of Strains from Patients with Uncomplicated Infections and from Women with Pelvic Inflammatory Disease

^* Channing Laboratory, Departments of Medical Microbiology and Medicine, Boston City Hospital, Boston, Massachusetts 02118,
¹ Department of Medicine, Harvard Medical School, Boston, Massachusetts, 02115

ABSTRACT

Minimum inhibitory concentrations (MICs) of six penicillins against 95 strains of Neisseria gonorrhoeae from patients with uncomplicated anogenital infections and 22 strains from women with pelvic inflammatory disease were determined by an agar plate dilution method, using an inocula replicator. Against all 117 strains, the order of activity observed was: BL-P1654 > penicillin X > penicillin G > ampicillin > amoxicillin = carbenicillin. MICs against strains isolated from women with gonococcal pelvic inflammatory disease were significantly higher than those against isolates from uncomplicated infections: BL-P1654, P < 0.001; penicillin X, P < 0.001; penicillin G, P < 0.001; ampicillin, P < 0.001; and amoxicillin, P < 0.05. MICs of penicillin G were 0.125 µg/ml against 33 (36%) of the 92 strains from patients with uncomplicated infections, as contrasted with 15 (68%) of the 22 isolates from women with pelvic inflammatory disease (P < 0.01). The means of the MICs of penicillin G were 0.06 µg/ml for the former and 0.14 µg/ml for the latter.