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Antimicrob Agents Chemother. 1977 July; 12(1): 47-50
Copyright © 1977 American Society for Microbiology. All Rights Reserved.

Cefuroxime, a New Parenteral Cephalosporin: Collaborative In Vitro Susceptibility Comparison with Cephalothin Against 5,887 Clinical Bacterial Isolates

^* Department of Pathology, Kaiser Foundation Hospital Laboratories, Portland, Oregon 97217
Department of Pathology, St. Vincent Hospital, Portland, Oregon 97225
Department of Microbiology, Cleveland Clinic Foundation, Cleveland, Ohio 44106
Microbiology Laboratory, St. Francis Hospital, Wichita, Kansas 67201
Clinical Microbiology Laboratory, University of California (Davis), Sacramento Medical Center, Sacramento, California 95817
Antimicrobic Investigation Section, Center for Disease Control, Atlanta, Georgia 30333

ABSTRACT

Cefuroxime, a new parenteral cephalosporin was compared with cephalothin by broth microdilution susceptibility testing against 5,887 routine clinical bacterial isolates in four large clinical laboratories. The minimal inhibitory concentrations (MICs) of cefuroxime against the Enterobacteriaceae were consistently lower than those of cephalothin. This was most striking among the Enterobacter species, which were generally susceptible to cefuroxime (MIC 8 µg/ml), but resistant to cephalothin. Similar results occurred with Haemophilus species, Acinetobacter anitratus, meningococci, and Aeromonas hydrophilia, but Pseudomonas species and enterococci were resistant to high concentrations of both drugs. Streptococci showed slightly greater susceptibility to cefuroxime than to cephalothin. By contrast, staphylococci were more susceptible to cephalothin. Bacteroides fragilis was resistant to cefuroxime, but other anaerobes were generally susceptible.

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